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Michael Novakhov – SharedNewsLinks℠: 7:01 AM 7/22/2020 – Does this mean that Mouse is the much more likely intermediary host than Bats and Pangolins?


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Frontiers | Analysis of Possible Intermediate Hosts of the New ...

Does this mean that Mouse is the much more likely intermediary host than Bats and Pangolins for Sars-Cov-2?

7:01 AM 7/22/2020

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The PRRA insert at the S1/S2 site modulates cellular tropism of SARS-CoV-2 and ACE2 usage by the closely related Bat raTG13 | bioRxiv

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The PRRA insert at the S1/S2 site modulates cellular tropism of SARS-CoV-2 and ACE2 usage by the closely related Bat raTG13

Shufeng LiuPrabhuanand SelvarajChristopher LienWells W. WuChao-Kai ChouTony Wang

Abstract

Biochemical and structural analyses suggest that SARS-CoV-2 is well-adapted to infecting human and the presence of four residues (PRRA) at the S1/S2 site within the Spike protein may lead to unexpected tissue or host tropism. Here we report that SARS-CoV-2 efficiently utilized ACE2 of 9 species except mouse to infect 293T cells. Similarly, pseudoviruses bearing spike protein derived from either the bat raTG13 or pangolin GX, two closely related animal coronaviruses, utilized ACE2 of a diverse range of animal species to gain entry. Removal of PRRA from SARS-CoV-2 Spike displayed distinct effects on pseudoviral entry into different cell types. Strikingly, insertion of PRRA into the raTG13 Spike selectively abrogated the usage of horseshoe bat and pangolin ACE2 but conferred usage of mouse ACE2 by the relevant pseudovirus to enter cells. Together, our findings identified a previously unrecognized effect of the PRRA insert on SARS-CoV-2 and raTG13 spike proteins.


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Blogs from Michael_Novakhov (23 sites) 
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Michael Novakhov – SharedNewsLinks 
The PRRA insert at the S1/S2 site modulates cellular tropism of SARS-CoV-2 and ACE2 usage by the closely related Bat raTG13 | bioRxiv
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Saved Stories

Saved Stories – None 
The PRRA insert at the S1/S2 site modulates cellular tropism of SARS-CoV-2 and ACE2 usage by the closely related Bat raTG13 | bioRxiv
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TWEETS BY MIKENOV from Michael_Novakhov (1 sites) 
mikenov on Twitter: Covid-19 came from europe, not china images.app.goo.gl/r37uoZgBrpBYEJ
mikenov on Twitter: Covid-19 came from europe, not china images.app.goo.gl/3cskZLDaHJf18U
mikenov on Twitter: Covid-19 came from europe, not china images.app.goo.gl/xrrUAXLDzdPhyv
mikenov on Twitter: Covid-19 came from europe, not china images.app.goo.gl/5cENAR5RqXprHH
mikenov on Twitter: images.app.goo.gl/SZJfvJxSG7WxPZ
mikenov on Twitter: Italys earliest coronavirus strains did not arrive from China, study suggests scmp.com/news/world/eur via @scmpnews
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mikenov on Twitter: COVID-19: Why blood clots are a leading cause for coronavirus deaths gn24.ae/a33c746b80fc000
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