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The Covid-19 Review

June 25, 2022 3:50 am

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Saved and Shared Stories from Michael Novakhov

Saved Stories – None: 7:40 AM 7/31/2020 – Cross-reactivity: Covid-19 and common cold Coronaviruses

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7:40 AM 7/31/2020

Could prior exposure to common cold viruses affect the severity of ...

Cross-reactivity: Covid-19 and common cold Coronaviruses

“So how could their immune system have reactive T cells if they never had Covid-19? They were “probably acquired in previous infections with endemic” coronaviruses, the researchers — from various institutions in Germany and the United Kingdom — wrote in the new study. Using this T cell memory from another-yet-similar infection to respond to a new infection is called “cross-reactivity.”

“Alessandro Sette and Shane Crotty, both of the University of California, San Diego, wrote in a comment paper published in the journal Nature earlier this month, that “20–50% of unexposed donors display significant reactivity to SARS-CoV-2 antigen peptide pools,” based on separate research — but they noted that the source and clinical relevance of the reactivity remains unknown.
Sette and Crotty wrote that “it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population. It is hypothesized, but not yet proven, that this might be due to immunity to” common cold coronaviruses.”

  1. We detected SARS-CoV-2 S-reactive CD4+ T cells in 83% of patients with COVID-19 but also in 35% of HD. S-reactive CD4+ T cells in HD reacted primarily to C-terminal S epitopes, which show a higher homology to spike glycoproteins… 

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